Doç. Dr. Aytül BAYRAKTAR
Biomühendislik Öğretim Üyesi
Cellular Therapies and Aesthetic
In recent years, a new approach has emerged, thanks to extensive research and advances in the field of cellular therapy.

It has been developed in the treatment of multiple conditions using autologous (taken from the person himself) and allogeneic (taken from another healthy donor) cells.

Today, research centers and knowledge-based organizations are achieving great success through cellular therapies.

Efforts to use these cells in the treatment of various conditions continue around the world.

The knowledge and practice of cellular therapy has many potential advantages.

Stem cells and somatic cells can be used in transplantation of different tissue types and stimulate other cells for repair through various cellular mechanisms such as intracellular interactions.

The use of functional cells with therapeutic activity can restore tissue functions with the direct contribution of cells.

These extraordinary properties highlight the importance of cellular therapy.

Emphasizing the importance of the use of cellular therapies in the field of Aesthetics, Associate Professor Aytül BAYRAKTAR, a faculty member in the field of Bioengineering, stated that this method, which is a response to external skin aging affected by environmental factors, is among the tremendous developments in the aesthetic medical field.

The skin is our body's most exposed organ against external attacks, and it acts as a barrier.

Some direct effects of environmental factors are UV radiation and air pollution exposure to the skin.

Changes in skin structure and physiology occur as natural results of aging and contribute to decreased skin health.

When these effects, which develop due to external factors, are combined with lifestyle, they can cause important biological changes that make the characteristics of premature aging.

External aging, which is affected by environmental factors, differs from natural aging, and differs among individuals and ethnic groups.

Exposure to high levels of UV radiation is the main cause of oxidative stress, which results in differential expression of endogenous antioxidant enzymes, protein oxidation, and lipid peroxidation.

The dermis and epidermis layers in the structure of the skin are affected by the exposure to sunlight and UV radiation.

In areas that are exposed to sunlight, deep and fine lines, wrinkles, rough and dry skin, dark spots in skin pigmentation, sagging and loss of elasticity are seen.

Fibroblast cells in the dermis layer of the skin are the basic cells of the connective tissue and have very important functions for the body.

They are one of the cells responsible for the production of collagen protein, which is the main substance of connective tissue, playing an important role in tissue repair, functioning in the healing of wounds, and providing vividness and flexibility to the skin.

Fibroblasts deteriorate over time, especially in sun-exposed areas of the skin, and their number decreases.

Thus, the elasticity of the skin is lost, wrinkles are formed, and conditions such as collapse and sagging of the skin can be observed.

Fibroblast cellular therapies have taken their place among the new methods in the treatment of various skin conditions.

By preventing cellular and skin aging, it provides structural durability and repair in the skin by interacting with the epidermis during skin rejuvenation, remodeling, and protection of the normal skin structure.

Dermal fibroblasts produce and regulate the extracellular matrix of the dermis.

They also communicate among each other and with other types of cells.

Fibroblasts play a crucial role in regulating skin physiology and cutaneous wound repair.

Fibroblasts are mesenchymal cells that play an important role in epithelial-mesenchymal reactions.

These cells also play a key role in epidermal proliferation and differentiation, and cellular matrix formation through different growth factors and the secretion of cytokines.

So far, conditions such as burns, diabetic wounds, scars, and aging skin have been treated with cellular therapies.

In cellular therapy, samples taken from the patient's skin are isolated and cultured, then injected into the damaged tissues.

In recent years, many clinical studies have been conducted in this area and countless studies have been published.

Interdisciplinary Studies of Engineering and Life sciences; In the field of regenerative medicine, it is used to repair diseased and injured cells, tissues, and all organs to support healing.

Regenerative medicine applications restore the structure and functions of damaged cells, tissues, or organs.

There are highly effective therapies especially in orthopedics, gynecology, urology, dermatology, and hair transplantation.

Regenerative medicine, which is based on stem cell technology, provides benefits to human life thanks to its different stem cell types, harvesting sources, methods, and many different applications in medical practice today.